The Science Behind the Stillness

The science of stress: why we get ill.

When we are under stress, the body stays in “fight or flight” mode. For a short period that is useful - it is what the response evolved for. Sustained across years, it becomes one of the most under-treated drivers of chronic disease.

By Dr Vimple Bhalani, MBBS MRCGP Part i of the Stillness series Last reviewed July 2026

What the stress response actually does

The sympathetic nervous system prepares the body for immediate physical threat. Heart rate and blood pressure rise, blood is redirected to muscle, glucose is released for fuel, digestion is suspended and the immune system shifts toward inflammation. It is an elegant piece of engineering for escaping danger.

The difficulty is that the same system responds to a deadline, a difficult relationship or a demanding job — threats that do not resolve in minutes. When the switch stays on, the consequences accumulate:

  • Cortisol remains elevated
  • Sleep becomes shorter and less restorative
  • Digestion is disrupted
  • Inflammatory activity increases
  • Blood pressure climbs and the heart works harder
  • Blood sugar regulation deteriorates
  • Anxiety, overwhelm, and fatigue set in

What it leads to over years

Sustained over a long enough period, this pattern is associated with hormonal imbalance, weakened immunity and slower recovery from illness, chronic pain, and eventually burnout. It is a contributing factor in a substantial share of the cardiovascular and metabolic disease seen in general practice — rarely the only cause, but frequently one of them.

01 · The Science of Stress

Why sustained stress makes us ill.

Under sustained stress, the body stays in ‘fight or flight’ mode.

Sympathetic nervous system — fight or flight


  • ↑ Cortisol (the stress hormone)
  • Poor sleep & recovery
  • Increased inflammation
  • Digestive problems
  • Higher blood pressure & heart strain
  • Anxiety & overwhelm
  • Fatigue & low energy

Sustained over years, this is associated with:

Hormonal imbalance
Weakened immunity
Chronic pain
Burnout

The good news: the body is designed to heal when it shifts into rest-and-repair mode.

The body is built to heal when it shifts into rest and repair. That shift is not mystical — it has an anatomical pathway, it can be measured, and it can be trained deliberately.

The part that is good news

The body is built to heal when it shifts into rest and repair. That shift is not mystical — it has an anatomical pathway, it can be measured, and it can be trained deliberately. Read about the vagus nerve →

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Medically reviewed

Reviewed by Dr Vimple Bhalani, MBBS MRCGP · GMC 6062199 · Last reviewed 17 September 2026